Stereo-seq Technology

STOmics’ Stereo-seq (SpaTial Enhanced REsolution Omics-sequencing) technology offers researchers ground-breaking spatial biology tools, providing unmatched field-of-view and subcellular resolution.

It enables simultaneous transcriptome capturing at tissue, cellular, subcellular, and molecular levels using fresh frozen tissue and Formalin-Fixed Paraffin-Embedded (FFPE) tissue. By capturing RNA in-situ and applying spatial coordination barcoding (CID), Stereo-seq generates spatial gene expression profiles using DNBSEQ™, advancing the understanding of gene expression, cell morphology, and microenvironments.

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Unlocking the Power of Spatial Transcriptomics

Stereo-se (SpaTial Enhanced REsolution Omics-sequencing) is a pioneering spatial technology that enables in-depth exploration of the whole transcriptome at true single-cell resolution. Utilizing a range of centimetre-level capturing chips, it stands as the only spatial technology capable of examining tissues from multiple species with unparalleled nanoscale resolution.

Stereo-seq is a powerful research tool for integrating gene expression, protein expression, and other multi-omics data. It offers advanced capabilities for cell type identification, tissue microenvironment exploration, and cellular/organ developmental research.

Integration of pathology and spatio-temporal omics

Our innovative staining approach made it possible to integrate the study of pathology and spatio-temporal analysis on the same tissue section.

Large field of view and high resolution

With up to decimetre-scale STOmics Chip and nanoscale DNB probes, subcellular level details can be collected from any position on an entire tissue section.

Multidimensional analysis

Ability to integrate the study of tissue staining sections with whole-genome mRNA transcriptomics and proteomics.

High compatibility

Stereo-seq is compatible with fresh frozen and FFPE samples, and has reliable performance on cells, organs and embryo sections of various species.

Stereo-seq integrates a DNB-patterned chip with Coordinate ID (CID) barcoding to capture mRNA directly from tissue sections while preserving native spatial information. Following library construction and sequencing, each transcript is mapped back to its original location, generating high-resolution spatial transcriptomic profiles across entire tissue sections. This powerful workflow enables researchers to visualize gene expression in its anatomical context and reveal the molecular architecture of complex tissues at unprecedented resolution and scale.
Workflow diagram of Stereo-seq technology: From DNB Patterned Chip and CID Sequencing to In Situ RNA Capture and Spatially Resolved Transcriptomics Profiling.

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Stereo-seq is reshaping spatial biology by empowering discoveries across four major application areas: Cancer & Disease, Neuroscience, Developmental Biology, and Plant Science. From constructing spatiotemporal atlases and uncovering evolutionary mechanisms to advancing disease diagnosis, prognosis, and therapeutic development, Stereo-seq enables researchers to investigate biological systems at unprecedented resolution and scale.
 
As Stereo-seq continues to evolve, future innovations will further expand its impact, revolutionizing our understanding of human biology and redefining how diseases are characterized, studied, and ultimately treated.
An infographic depicting four primary application areas of Stereo-seq technology: Cancer, Neuroscience, Organoid, and Plant research.

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